Case Report
Remission of Aripiprazole-induced Tardive Dyskinesia with Valbenazine and Vitamin E Combination Therapy: A Case Report
Issue:
Volume 13, Issue 3, September 2025
Pages:
77-84
Received:
12 July 2025
Accepted:
28 July 2025
Published:
12 August 2025
Abstract: Antipsychotic medications comprise a cornerstone for the management of multiple psychopathologies, but their use is associated with significant side effects. Tardive dyskinesia (TD) is one such effect that is particularly troublesome. TD is clinically distressing, hard to treat, and poorly understood by the medical community. Due to these challenges, second-generation antipsychotics, such as aripiprazole, tend to be favored for their reduced risk of TD; however, rare cases of aripiprazole-induced TD have been documented. This report presents a novel case of TD secondary to aripiprazole monotherapy, managed successfully with Valbenazine and Vitamin E. A 39-year-old woman with schizophrenia was treated with aripiprazole, titrated to 30 mg daily. Though her psychotic symptoms improved significantly, she developed clinically distressing moderate-severe TD symptoms after one year of treatment. Her dose of aripiprazole dose was reduced, and a combination of Valbenazine 40 mg and Vitamin E 400 mg daily was initiated. This intervention led to substantial improvement, allowing the patient to achieve remission of TD symptoms and improvement in her psychiatric symptoms. This improvement persisted for over a year, even after the patient independently elected to discontinue Valbenazine therapy. Although recent case reports display clozapine as therapeutic for Aripiprazole-induced TD, the risks associated with clozapine necessitate alternative strategies for management of TD symptoms. The successful use of Valbenazine and Vitamin E in this case suggests a potentially safer and more accessible treatment option. This case study also supports the oxidative stress hypothesis of TD pathogenesis, and highlights the need for early screening, recognition, and intervention in TD to improve patient outcomes.
Abstract: Antipsychotic medications comprise a cornerstone for the management of multiple psychopathologies, but their use is associated with significant side effects. Tardive dyskinesia (TD) is one such effect that is particularly troublesome. TD is clinically distressing, hard to treat, and poorly understood by the medical community. Due to these challenge...
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Research Article
Incest Revealed in the Work of Niki Saint Phalle
Issue:
Volume 13, Issue 3, September 2025
Pages:
85-88
Received:
10 July 2025
Accepted:
29 July 2025
Published:
19 August 2025
Abstract: Niki Saint Phalle revealed her incest at age sixty two in a book called “My Secret”. She revealed it also unconsciously before in the pictural, sculptural and cinematographic work. (a woman protecting herself from a dragon a self portrait with a double mouth, the Nanas, the love mouth of the Stavinski fountain), Freud the first showed us the path with the interpretation of the paintings of Leonardo da Vinci. The incest had consequences: self-arm, feelings of being excluded from the society, impossibility to tell her mother, headaches, hate towards her father, a breakdown and no recognition. of psychiatrists The sublimation in painting and sculpture, and in her movie Daddy was a way to elaborate the sexual traumatism. She was able to develop an imaginary life thanks to her hysterical personality. Creation helped her to feel better and sooth anxiety, shame and guilt. Her book My Secret can be considered as a self-analysis. The rape developed in her, fantasies and sadistic sexual drives by identification to the aggressor that we find in her movie Daddy. Her book “My secret” brings the material like in a psychoanalytic session with free association. Niki Saint Phalle did a remarkable self-analysis of her sexual traumatism, with words.
Abstract: Niki Saint Phalle revealed her incest at age sixty two in a book called “My Secret”. She revealed it also unconsciously before in the pictural, sculptural and cinematographic work. (a woman protecting herself from a dragon a self portrait with a double mouth, the Nanas, the love mouth of the Stavinski fountain), Freud the first showed us the path w...
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Research Article
Study of Psychiatric Comorbidities in Patients Diagnosed with Alcohol Dependence Syndrome in Kathmandu Medical College
Sushil Samadarshi,
Sudarshan Narsing Pradhan,
Asmita Khanal*
Issue:
Volume 13, Issue 3, September 2025
Pages:
89-101
Received:
23 July 2025
Accepted:
8 August 2025
Published:
26 August 2025
Abstract: Background: There has been a considerable increase in number of people who are diagnosed with Alcohol Dependence Syndrome (ADS). Psychiatric comorbidities are found in high proportion in association with ADS. Depressive disorders, anxiety and other psychiatric disorders are diagnosed in patients with ADS with bidirectional relationship and a high proportion of relapses are attributable to these comorbidities. Methods: A descriptive cross-sectional study was conducted over one year in the psychiatric inpatient department of Kathmandu Medical College Teaching Hospital. Sixty-one patients diagnosed with ADS based on ICD-10 DCR criteria were enrolled. Psychiatric comorbidities were assessed using the ICD -10 guidelines. Beck Depression Inventory (BDI) and Beck Anxiety Inventory (BAI) scores were used to assess depressive and anxiety disorders with their severity. Results: Out of 61 patients with ADS, 78.7% had psychiatric comorbidities. Depressive disorders in (35.4%), anxiety disorders in (27.1%), psychotic disorders in (18.8%), bipolar affective disorder (10.4%), and personality disorder (8.3%) were common diagnoses made. Moderate to severe depression and anxiety were most common psychiatric comorbidities. Conclusion: Psychiatric comorbidities are highly prevalent among ADS patients. Integrated management approaches addressing both mental and physical health, along with caregiver support, are essential to improve health outcomes and reduce relapse in ADS.
Abstract: Background: There has been a considerable increase in number of people who are diagnosed with Alcohol Dependence Syndrome (ADS). Psychiatric comorbidities are found in high proportion in association with ADS. Depressive disorders, anxiety and other psychiatric disorders are diagnosed in patients with ADS with bidirectional relationship and a high p...
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