-
Case Report
Remission of Aripiprazole-induced Tardive Dyskinesia with Valbenazine and Vitamin E Combination Therapy: A Case Report
Issue:
Volume 13, Issue 3, September 2025
Pages:
77-84
Received:
12 July 2025
Accepted:
28 July 2025
Published:
12 August 2025
Abstract: Antipsychotic medications comprise a cornerstone for the management of multiple psychopathologies, but their use is associated with significant side effects. Tardive dyskinesia (TD) is one such effect that is particularly troublesome. TD is clinically distressing, hard to treat, and poorly understood by the medical community. Due to these challenges, second-generation antipsychotics, such as aripiprazole, tend to be favored for their reduced risk of TD; however, rare cases of aripiprazole-induced TD have been documented. This report presents a novel case of TD secondary to aripiprazole monotherapy, managed successfully with Valbenazine and Vitamin E. A 39-year-old woman with schizophrenia was treated with aripiprazole, titrated to 30 mg daily. Though her psychotic symptoms improved significantly, she developed clinically distressing moderate-severe TD symptoms after one year of treatment. Her dose of aripiprazole dose was reduced, and a combination of Valbenazine 40 mg and Vitamin E 400 mg daily was initiated. This intervention led to substantial improvement, allowing the patient to achieve remission of TD symptoms and improvement in her psychiatric symptoms. This improvement persisted for over a year, even after the patient independently elected to discontinue Valbenazine therapy. Although recent case reports display clozapine as therapeutic for Aripiprazole-induced TD, the risks associated with clozapine necessitate alternative strategies for management of TD symptoms. The successful use of Valbenazine and Vitamin E in this case suggests a potentially safer and more accessible treatment option. This case study also supports the oxidative stress hypothesis of TD pathogenesis, and highlights the need for early screening, recognition, and intervention in TD to improve patient outcomes.
Abstract: Antipsychotic medications comprise a cornerstone for the management of multiple psychopathologies, but their use is associated with significant side effects. Tardive dyskinesia (TD) is one such effect that is particularly troublesome. TD is clinically distressing, hard to treat, and poorly understood by the medical community. Due to these challenge...
Show More
-
Research Article
Incest Revealed in the Work of Niki Saint Phalle
Issue:
Volume 13, Issue 3, September 2025
Pages:
85-88
Received:
10 July 2025
Accepted:
29 July 2025
Published:
19 August 2025
Abstract: Niki Saint Phalle revealed her incest at age sixty two in a book called “My Secret”. She revealed it also unconsciously before in the pictural, sculptural and cinematographic work. (a woman protecting herself from a dragon a self portrait with a double mouth, the Nanas, the love mouth of the Stavinski fountain), Freud the first showed us the path with the interpretation of the paintings of Leonardo da Vinci. The incest had consequences: self-arm, feelings of being excluded from the society, impossibility to tell her mother, headaches, hate towards her father, a breakdown and no recognition. of psychiatrists The sublimation in painting and sculpture, and in her movie Daddy was a way to elaborate the sexual traumatism. She was able to develop an imaginary life thanks to her hysterical personality. Creation helped her to feel better and sooth anxiety, shame and guilt. Her book My Secret can be considered as a self-analysis. The rape developed in her, fantasies and sadistic sexual drives by identification to the aggressor that we find in her movie Daddy. Her book “My secret” brings the material like in a psychoanalytic session with free association. Niki Saint Phalle did a remarkable self-analysis of her sexual traumatism, with words.
Abstract: Niki Saint Phalle revealed her incest at age sixty two in a book called “My Secret”. She revealed it also unconsciously before in the pictural, sculptural and cinematographic work. (a woman protecting herself from a dragon a self portrait with a double mouth, the Nanas, the love mouth of the Stavinski fountain), Freud the first showed us the path w...
Show More
-
Research Article
Study of Psychiatric Comorbidities in Patients Diagnosed with Alcohol Dependence Syndrome in Kathmandu Medical College
Sushil Samadarshi,
Sudarshan Narsing Pradhan,
Asmita Khanal*
Issue:
Volume 13, Issue 3, September 2025
Pages:
89-101
Received:
23 July 2025
Accepted:
8 August 2025
Published:
26 August 2025
Abstract: Background: There has been a considerable increase in number of people who are diagnosed with Alcohol Dependence Syndrome (ADS). Psychiatric comorbidities are found in high proportion in association with ADS. Depressive disorders, anxiety and other psychiatric disorders are diagnosed in patients with ADS with bidirectional relationship and a high proportion of relapses are attributable to these comorbidities. Methods: A descriptive cross-sectional study was conducted over one year in the psychiatric inpatient department of Kathmandu Medical College Teaching Hospital. Sixty-one patients diagnosed with ADS based on ICD-10 DCR criteria were enrolled. Psychiatric comorbidities were assessed using the ICD -10 guidelines. Beck Depression Inventory (BDI) and Beck Anxiety Inventory (BAI) scores were used to assess depressive and anxiety disorders with their severity. Results: Out of 61 patients with ADS, 78.7% had psychiatric comorbidities. Depressive disorders in (35.4%), anxiety disorders in (27.1%), psychotic disorders in (18.8%), bipolar affective disorder (10.4%), and personality disorder (8.3%) were common diagnoses made. Moderate to severe depression and anxiety were most common psychiatric comorbidities. Conclusion: Psychiatric comorbidities are highly prevalent among ADS patients. Integrated management approaches addressing both mental and physical health, along with caregiver support, are essential to improve health outcomes and reduce relapse in ADS.
Abstract: Background: There has been a considerable increase in number of people who are diagnosed with Alcohol Dependence Syndrome (ADS). Psychiatric comorbidities are found in high proportion in association with ADS. Depressive disorders, anxiety and other psychiatric disorders are diagnosed in patients with ADS with bidirectional relationship and a high p...
Show More
-
Research Article
Post-Traumatic Stress Disorder (PTSD) in Irregular Migrants Back to Ziguinchor (Senegal): Prevalence and Associated Factors
Adama Koundoul*,
Babacar Diop,
Issa Wone,
Diariatou Seck,
Abdou Khadre Dieng,
Sokhna Seck,
El Hadji Makhtar Ba,
Aida Sylla
Issue:
Volume 13, Issue 3, September 2025
Pages:
102-117
Received:
18 August 2025
Accepted:
29 August 2025
Published:
25 September 2025
Abstract: Introduction: The migration of the Senegalese to the Eldorado has continued to increase since 2006. It has become massive and clandestine, and candidates do not hesitate to use illegal and dangerous ways and means, thus exposing their lives and engaging their physical and psychological integrity. Objectives: Determine the prevalence of PTSD in migrants and identify the factors associated with its occurrence. Methodology: A descriptive and analytical transversal study on migrants had been carried out in Ziguinchor over the period from January 1 to July 31, 2024. The collection of data was done on the basis of the PCL-5 (PTSD Checklist for DSM-5) evaluation scale and a pre-established questionnaire. The entry was made on Excel spreadsheet and statistical analysis with the STATA 18 software. Results: A total of 41 migrants had been surveyed. The study population was made up of men (92.7%). The average age was 36.9 years ± 9.3. Migrants had attended school (70.7%) and had professional activity before departure (92.7%). They were craftsmen (39.0%) and single without children (46.3%). Motivation to emigration was linked to financial difficulties (85.4%). Italy was the chosen destination 58.5%. The privileged travel route was terrestrial (70.7%). Thirty-five migrants had encountered difficulties during the trip. The return to the country was against their will (63.4%). The prevalence of the PTSD was 31.7%. Its occurrence was favored by borrowing the land route, by the difficulties linked to food and extortion. Literacy was a protective factor. The PTSD impacted on social reintegration but had no impact on professional reintegration and the desire to return. Conclusion: The study has shown a fairly high frequency of PTSD in migrants related to traumatic events experienced during the trip. It is therefore necessary to assess all the migrants on the health level and to ensure them a medico-psychosocial care.
Abstract: Introduction: The migration of the Senegalese to the Eldorado has continued to increase since 2006. It has become massive and clandestine, and candidates do not hesitate to use illegal and dangerous ways and means, thus exposing their lives and engaging their physical and psychological integrity. Objectives: Determine the prevalence of PTSD in migr...
Show More
-
Editorial
At the Crossroads of Times for a Transcultural Clinic: Between Psychic Subjectivity and Institutional Requirements
Serigne Souaïbou Ba*,
Bachir Mansour Diallo,
Malick Ngom,
Karim Madiyiri Pouabizan,
Papa Souleymane Seck,
Abdou Khadre Dieng,
Mamadou Sissokho,
Marie Jo Bourdin
Issue:
Volume 13, Issue 3, September 2025
Pages:
118-121
Received:
1 September 2025
Accepted:
12 September 2025
Published:
26 September 2025
Abstract: Introduction: In psychiatry, the therapeutic act is not limited to the administration of treatment. It unfolds in a temporal dimension which goes beyond simple chronological measurement. The psychiatric institution is a care system acting as a space of reconfiguration, offering a framework where subjectivity can be reorganized. However, contemporary psychiatry is crossed by a tension of time between: that of the patient, that of care and that of the hospital organization, subject to logistical and managerial constraints. Between an African heritage where time is experienced in circularity and the linear Western model, oriented towards efficiency, the mix of both seems disturbing. Methodology: Through this article adopting a critical and comparative stance around this question, the authors plead for an ethics of time in care. A review of the literature was carried out through a targeted selection of studies. It was at the junction of anthropological and philosophical theories but also of the psychiatric clinic. Indeed, the professional experiences of the authors also made it possible to carry out an analysis of the areas of shock and overlap. The objective was to put in place a reflection in order to give “time” its therapeutic value at the crossroads of different cultural frameworks. Conclusion: Psychiatric care is a complex weave of temporalities that can conflict, but also harmonize. At the crossroads of cultures, the caregiver is led to allow everyone to find their own rhythm towards healing. To do this, we must rethink our relationship with what cannot be measured: the silence, the waiting, the duration which is the very heart of care.
Abstract: Introduction: In psychiatry, the therapeutic act is not limited to the administration of treatment. It unfolds in a temporal dimension which goes beyond simple chronological measurement. The psychiatric institution is a care system acting as a space of reconfiguration, offering a framework where subjectivity can be reorganized. However, contemporar...
Show More
