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Endolumbal Nootropic-Ozone Therapy in Complex Treatment of Patients with Complicated Spinal Injury in Acute Period
Issue:
Volume 1, Issue 1, July 2013
Pages:
1-4
Received:
14 May 2013
Published:
10 June 2013
Abstract: Spinal trau ma occurs when there is damage to the spinal cord that results in a bruise, a partial tear, or a complete tear. Because the spinal cord is the central carrier of signals throughout the body, damage to the spinal cord can have serious consequences. During a 5 - year period (2005 – 2009), 39 patient’s spinal trauma – were treated in the Neurology department of RCSUMA. The patients were divided into two groups: The first group (main) included 25 patients, spinal injury complicated by different localization. The main criterion for evaluating the effectiveness of this method is clinic neurologic, liquor dynamic and liquorlogical: the emergence of positive neurological symptoms within two weeks after endolumbal nootropic-ozone therapy. 16 patients (64.0%) have after 2-3 times endolumbal nootropic-ozone therapy has appeared positive neurological symptoms as return of sensation the below level of damage and slight movement in the limbs. In 6 (24.0%) patients improved neurological symptoms occurred after 5-6 times the endolumbal nootropic-ozone therapy. In the control group from 5 (35.7%) patients after repeated carrying out endolumbal nootropic-ozone therapy in postoperative period there was not much positive neurological symptomatology and 9 (64.3%) even patients in postoperative period it remained the same. Received in the dynamics of the lumbar puncture data sanation and liquor dynamic tests have shown that improving the patency of liquor content spaces of spinal cord after 2-3 times a endolumbal nootropic-ozone therapy in 70.0% of cases, and data liqoulogical studies have shown that when endolumbal nootropic-ozone therapy the sanation of liquor was already in the first 3-4 days after injury, while patients control group has the full purifying liquor 8-10 per day. Professionally conducted decompression-stabilizing operations on the spine with the use of endolumbal nootropic-ozone therapy, patients with complicated spinal injury in acute period of injury significantly improves both the results of the treatment and nevrologic symptoms that reduces disability, and this positively affects the quality of life of these traumas.
Abstract: Spinal trau ma occurs when there is damage to the spinal cord that results in a bruise, a partial tear, or a complete tear. Because the spinal cord is the central carrier of signals throughout the body, damage to the spinal cord can have serious consequences. During a 5 - year period (2005 – 2009), 39 patient’s spinal trauma – were treated in the N...
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Behavioral Consequences of Chronic Stress and Effects of Antidepressant Treatment on Animal Models of Depression
Ritabrata Banerjee,
Somoday Hazra,
Sourav Kumar,
Anup K. Ghosh,
Amal C. Mondal
Issue:
Volume 1, Issue 1, July 2013
Pages:
5-13
Received:
24 June 2013
Published:
10 July 2013
Abstract: Major depression has a high prevalence and a high mortality. In order to understand the molecular changes underlying major depression animal models are needed. The different animal models of depression simulate the etiology and replicates symptoms, course and treatment of human depression properly. In this study, we investigated stress-induced depressogenic induction among the rats using Shuttle Box Escape Test, Open Field Test (OFT) and Elevated Plus Maze (EPM) Test. Fluoxetine hydrochloride (FLX), an antidepressant was administered chronically to determine antidepressant mediated recovery of their behavioral homeostasis. In addition, all the behavioral tests demonstrated a variety of specific symptoms like changes in locomotor activity, impaired learning ability and cognition deficit etc. From these findings, we can conclude that chronic inescapable foot-shocks at 0.8mA intensity for 15 sec duration are the most effective stressor to produce animal model of depression. After exposure to chronic foot-shocks, FLX mediated recovery strengthen our findings. In addition, the rats were screened through shuttle box escape test that mimic depressive-like behavior properly in animals. Our observation clearly corroborates well with the learned helplessness (LH) paradigm. So, the animal models of depression using electric foot-shock to induce depressive like behavior, have excellent face validity and replicate anhedonia and anergia in analogy to loss of interest and pleasure.
Abstract: Major depression has a high prevalence and a high mortality. In order to understand the molecular changes underlying major depression animal models are needed. The different animal models of depression simulate the etiology and replicates symptoms, course and treatment of human depression properly. In this study, we investigated stress-induced depr...
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The Role of Beta-Adrenergic Receptor Blockers in Autism
Khanh vinh quốc Lương,
Lan Thi Hoàng Nguyễn
Issue:
Volume 1, Issue 1, July 2013
Pages:
14-21
Received:
25 June 2013
Published:
10 August 2013
Abstract: β-adrenergic receptor blockade has been demonstrated to benefit individuals with autism. Genetic studies have identified numerous factors linking β-adrenergic receptor blockade to autism spectrum disorder (ASD), including β-adrenergic receptor variants, human leukocyte antigen genes, apoptotics factor caspase-3, glycogen synthetase kinase-3β, and the reduced form of nicotinamide adenine dinucleotide phosphate. β-adrenergic receptor blockade has also been implicated in ASD via its effects on myelin basic protein, prostaglandins, cyclooxygenase-2, and nitric oxide synthase. β-adrenergic receptor blockade may have a significant role in ASD.Therefore, the characterization of β-adrenergic receptor blockade in individuals with ASD is needed.
Abstract: β-adrenergic receptor blockade has been demonstrated to benefit individuals with autism. Genetic studies have identified numerous factors linking β-adrenergic receptor blockade to autism spectrum disorder (ASD), including β-adrenergic receptor variants, human leukocyte antigen genes, apoptotics factor caspase-3, glycogen synthetase kinase-3β, and t...
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