The Demographic Characteristics and the Risk Factors of Dementia in SAUDI Elderly
Muneerah Albugami,
Najeeb Qadi,
Fahed Almugbel,
Alaa Mohammed,
Alawi Alttas,
Abdelazeim Elamin,
Mumin Siddiquee,
Usama El Alem,
Yasmin Al Twaijri
Issue:
Volume 6, Issue 1, March 2018
Pages:
1-8
Received:
30 November 2017
Accepted:
8 December 2017
Published:
10 January 2018
Abstract: There is a little information about dementia in Saudis. This is a retrospective chart review study from1995 -2010. to describe the demographic characteristics and the risk factors of dementia, the prevalence of different types of dementia, and the current clinical practice of dementia in Saudi tertiary care hospital. A total of 418 demented patients (236 males, 182 females) their mean age was 78.8. Prevalence of diabetes 32%, hypertension 71.53%, dyslipidemia 30.05% and depression 24.41%. Clinically 64.37% of patients had memory impairment, 54.25% had confusion and 34.63% had personality changing. The commonest type of dementia was mixed dementia 18.37% followed by Alzheimer disease15.87%. 16.10% of patients had received cholinesterase inhibitor and 9.78% had received memantine. Infection was the commonest cause of frequent admission (40%) Mortality rate was 77.99%. The commonest cause of death was infection (38.34%) followed by cardiovascular causes like stroke (23.34%) and cardiac diseases (17.48%). Conclusion: (1) Mixed dementia is the commonest type of dementia in Saudis due to high prevalence of cardiovascular diseases risk factors. (2) High prevalence of depression among demented Saudi patients. It requires early recognition and treatment. (3) Demented patients have frequent admissions and long stay in hospital which makes the economic cost is very high. (4) Mortality rate among demented patients is high and the outcome of dementia is expected to be poor. The underlying message of this study is to increase awareness of the public and health system about the impact of dementia in Saudis and the need for prevention strategies, trained physicians and more research.
Abstract: There is a little information about dementia in Saudis. This is a retrospective chart review study from1995 -2010. to describe the demographic characteristics and the risk factors of dementia, the prevalence of different types of dementia, and the current clinical practice of dementia in Saudi tertiary care hospital. A total of 418 demented patient...
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Comparative Evaluation of Glibenclamide and Insulin on the Pups’ Liver Cytoarchitectonic Properties and Some Dams’ Parameters in Pregnant Streptozotocin-Induced Diabetic Rats
Lawal e Sodiq Kolawol,
Adeniji Adeoluwa Akeem,
Sangoyomi Oluwaseun Adewoye,
Adeyemo Rasheed Omotayo,
Buhari Muhammad Olanrewaju,
Sulaiman Sheu Oluwadare,
Osinubi Abraham Adewale
Issue:
Volume 6, Issue 1, March 2018
Pages:
9-14
Received:
21 November 2017
Accepted:
6 December 2017
Published:
11 January 2018
Abstract: Despite the significant achievements in the treatment modalities and preventive measures, the prevalence of gestational diabetes in Africa has continued to rise exponentially in the last few decades. There is growing concern on the use of oral hypoglycemic agents (OHAs) during pregnancy, due to the potential of the agents in causing adverse effect (s) on the developing fetus and its effectiveness in managing the gestational diabetes mellitus. The objective of this study was to investigate the action of glibenclamide compared with insulin on pups’ liver cytoarchitectonic property and oxidative stress markers, and on maternal glucose level and sexual hormonal profile. Twenty pregnant female Sprague-Dawley rats (120-160 g) divided into 4 groups A, B, C and D (n=5 per group) were used for the study. Rats in group A (control) were given 0.5ml distilled water daily while the rats in groups B, C, and D were rendered diabetic by administration of intraperitoneal low-dose streptozotocin (STZ) and subsequently treated with 0.5mls of distilled water, glibenclamide (0.29 mg/kg body weight) and insulin (1 UI daily) respectively. Blood glucose levels were monitored and recorded throughout the experiment. The rats were sacrificed on the 19th day of gestational period. The pups’ liver and maternal blood sample were collected for analysis. The glibenclamide and insulin groups showed significant (p≤0.05) decreased in blood glucose with an increased maternal body weight when compared to the diabetic group. The activities of GSH, SOD and CAT were significantly increased (p≤0.05) in the glibenclamide and insulin treated groups compared to the diabetic group. Also, MDA significantly reduced in the glibenclamide and insulin treated groups (C & D) when compared to the diabetic untreated group (B) with the greater reduction observed for insulin. There was an improvement in the hormonal profiles of glibenclamide and insulin treated groups compared with the diabetic group. Histologically, glibenclamide and insulin showed an improvement in the arrangement of cytoarchitectonic property of pups’ liver with mild steatosis compared with diabetic group. Based on our observations in this study, it was concluded that glibenclamide is as effective as insulin with no or little negative effect and could be an optional drug to be used in the treatment of gestational diabetes mellitus in place of insulin.
Abstract: Despite the significant achievements in the treatment modalities and preventive measures, the prevalence of gestational diabetes in Africa has continued to rise exponentially in the last few decades. There is growing concern on the use of oral hypoglycemic agents (OHAs) during pregnancy, due to the potential of the agents in causing adverse effect ...
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Caregiver’s Knowledge and Attitude Regarding Care of Schizophrenia at Mathari Teaching and Referral Hospital, Kenya
Edna Anab,
Agatha Christine Onyango,
Catherine Mwenda
Issue:
Volume 6, Issue 1, March 2018
Pages:
15-27
Received:
20 November 2017
Accepted:
8 December 2017
Published:
16 January 2018
Abstract: Schizophrenia is a mental disorder which is a major public health concern since it affects the quality of life of the schizophrenic patient. The patient requires a caregiver to support them in the entire phase of the condition. Caregiver’s knowledge facilitate recognition of mental illness and health-seeking behavior. The aim of the study was to assess the caregiver knowledge and attitude regarding care of Schizophrenia. The study was conducted at Mathari Teaching and Referral Hospital, Kenya where the respondents were the caregivers of the schizophrenic patients. The research design used was cross-sectional mixed method. A total of three hundred and three respondents participated in the study, the respondents were selected by utilizing systemic sampling technique. A list was generated as the sampling frame every 3rd patient on the list was selected. All the caregivers of the patient had an equal chance of participating in the study. Data collection instruments used were an objectively structured questionnaire and key informant guide which were used to solicit both qualitative and quantitative data. Descriptive statistics mainly measure of central tendency was used. Pearson correlation coefficient and logistic regression were used to determine the magnitude of the correlation. Qualitative data were analyzed through content analysis, similar themes were grouped. The findings indicate majority of the respondents 191 (63%) were female while 218 (72%) of the respondents did not know the name of the condition the patient was diagnosed with. Knowledge on schizophrenia significantly depended on the age of the caregiver (Pr = 0.001) and the length of time the caregiver had taken care of the patient and knowing the patient (Pr = 0.001) (Pearson chi2). Further modelling of these variables using logistic regression showed that caregivers’ who have spent a long period with the patient are 3 times more likely to have a more positive attitude and be more knowledgeable compared to those who have spent a lesser period with a schizophrenic patient. The variable period with the patient is the most meaningful variable compared to the other variables in the model. Increasing the level of knowledge regarding the condition makes the caregiver more effective in their role as the patient’s support system. These findings are a good opportunity for the formulation of interventions based on the identified gaps resulting to caregiver’s full involvement in the care and management of the patient.
Abstract: Schizophrenia is a mental disorder which is a major public health concern since it affects the quality of life of the schizophrenic patient. The patient requires a caregiver to support them in the entire phase of the condition. Caregiver’s knowledge facilitate recognition of mental illness and health-seeking behavior. The aim of the study was to as...
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