Special Issue on Extracellular Vesicular (EV) Content as Biomarkers and Therapies of Combat-related Morbidities

Submission Deadline: Oct. 15, 2020

Please click the link to know more about Manuscript Preparation: http://www.psychiatneurosci.org/submission

This special issue currently is open for paper submission and guest editor application.

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Special Issue Flyer (PDF)
  • Lead Guest Editor
    • Battlefield Pain Management, Burn and Soft Tissue Research, US Army Institute of Surgical Research, JBSA Ft. Sam Houston, USA
  • Guest Editor
    Guest Editors play a significant role in a special issue. They maintain the quality of published research and enhance the special issue’s impact. If you would like to be a Guest Editor or recommend a colleague as a Guest Editor of this special issue, please Click here to complete the Guest Editor application.
    • John Clifford
      Battlefield Pain Management, Burn and Soft Tissue Research, JBSA Ft. Sam Houston, USA
    • Shanmugasundaram Natesan
      Burn and Soft Tissue Research, US Army Institute of Surgical Research, JBSA Ft. Sam Houston, USA
    • Farr Niere
      Physiology and Pharmacology Department, Wake Forest University School of Medicine, Winston, USA
    • Arezoo Mohammadipoor
      Expeditionary Critical Care Research Department, US Army Institute of Surgical Research, JBSA Ft. Sam Houston, USA
    • Sanjeev Namjoshi
      Cancer Biology Department, Wake Forest Baptist Medical Center, Winston, USA
    • Nicholas Clay
      Burn and Soft Tissue Research, US Army Institute of Surgical Research, JBSA Ft. Sam Houston, USA
  • Introduction

    There is a need for non-invasive biomarkers and novel therapies for combat persistent injuries, including injury-induced inflammation and pain as well as the combat stress reaction (CSR). Service Members are exposed to adversarial conditions that can result in sustained combat injuries. Therefore, a major research goal is to understand the mechanisms that underlie these injuries to identify and test novel therapeutics. Inflammation and pain is experienced as a result of all combat-related injuries and can be exacerbated by physical and psychological stress. The combat stress reaction (CSR), experienced as a direct result of battlefield stress exposure, exhibits as a collection of autonomic nervous system symptoms, such as exhaustion, that function to limit the Service Member’s performance. In extreme hostile conditions, the ratio can be as high as 1:1 for CSR to battle casualties. Currently, knowledge pertaining to biomarkers for inflammation, CSR, pain development, and other combat-related injuries is severely lacking. In this special issue, we explore extracellular vesicular (EV) content as biomarkers and therapies of combat-related morbidities. This research is also quite applicable to civilian-sustained injuries.
    EV contained content are attractive biomarker candidates due to their conservation across species, stability in liquid biopsies, and variation that corresponds to a pathologic state. miRNA, mRNA, and protein can be sorted into EVs within the cell and released from a site of injury followed by endocytosis by adjacent or distant target cells. Upon uptake, the EV content can function to affect various signaling pathways that may contribute to inflammation, pain, CSR, or other combat-related morbidities. Previously, we discovered several potential biomarkers of nerve injury and for the development of neuropathic pain. The focus of this previous study was to determine the plasma derived EV miRNA content in a neuropathic pain model (Sosanya et al., 2019, J Pain). In this proposed special issue, we explore research in the use of EV content as biomarkers and therapies for inflammation, pain, CSR, and other combat-related morbidities.
    Aims and Scope:
    1. Combat-related injuries
    2. Extracellular vesicles
    3. Pain
    4. Stress
    5. Inflammation
    6. EV based therapies

  • Guidelines for Submission

    Manuscripts can be submitted until the expiry of the deadline. Submissions must be previously unpublished and may not be under consideration elsewhere.

    Papers should be formatted according to the guidelines for authors (see: http://www.psychiatneurosci.org/submission). By submitting your manuscripts to the special issue, you are acknowledging that you accept the rules established for publication of manuscripts, including agreement to pay the Article Processing Charges for the manuscripts. Manuscripts should be submitted electronically through the online manuscript submission system at http://www.sciencepublishinggroup.com/login. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal and will be listed together on the special issue website.

  • Published Papers

    The special issue currently is open for paper submission. Potential authors are humbly requested to submit an electronic copy of their complete manuscript by clicking here.