Volume 8, Issue 3, September 2020, Page: 50-58
Revisiting Clozapine in a Setting of COVID-19
James Paul Pandarakalam, North West Boroughs Healthcare NHS Foundation Trust & AFG Rehab Hospitals, Hollins Park Hospital, Warrington, UK
Received: Jul. 16, 2020;       Accepted: Jul. 28, 2020;       Published: Aug. 18, 2020
DOI: 10.11648/j.ajpn.20200803.12      View  50      Downloads  32
Clozapine is a highly potent atypical antipsychotic popularly used for treating refractory schizophrenia. Clozapine displays a complex mechanism of action. There are emerging views that its mode of action is immunomodulation rather than neuromodulation. It must be the immunomodulatory properties of clozapine that contributes to its superior efficacy and such a view help to validate the autoimmune ethology of a subset of schizophrenia. Agranulocytosis, one of the major side effects of clozapine is thought to be an autoimmune reaction. Because higher incidence of Flu related complications has been reported among clozapine users, there has been concern about the impact of COVID-19 among the patients on clozapine. As in the case of general population, infections with SARS-CoV-2 have been reported among clozapine users, but these are early days to make any firm conclusions about the higher risks of COVID-19 posing to clozapine treated patients. It is possible that clozapine may have therapeutic effects other than its antipsychotic effect and that needs further exploration.
Clozapine, Neuromodulation, Immunomodulation, Agranulocytosis, COVID-19, Autoimmune Reaction
To cite this article
James Paul Pandarakalam, Revisiting Clozapine in a Setting of COVID-19, American Journal of Psychiatry and Neuroscience. Vol. 8, No. 3, 2020, pp. 50-58. doi: 10.11648/j.ajpn.20200803.12
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