Volume 7, Issue 1, March 2019, Page: 8-11
Peduncular Hallucinosis and Overlapping Antiganglioside Antibody Syndrome
Alexis Demas, Department of Neurology, Hospital Jacques Monod, Le Havre, France
Guillaume Costentin, Department of Neurology, University Hospital Charles Nicolle, Rouen, France
Vincent Langlois, Department of Internal Medicine and Infectious Diseases, Hospital Jacques Monod, Le Havre, France
Yvan Vaschalde, Department of Neurology, Hospital Jacques Monod, Le Havre, France
Jean Philippe Cochin, Department of Neurology, Hospital Jacques Monod, Le Havre, France
Received: Nov. 15, 2018;       Accepted: Dec. 17, 2018;       Published: May 27, 2019
DOI: 10.11648/j.ajpn.20190701.12      View  184      Downloads  43
Abstract
Guillain Barre Syndrome (GBS), Miller Fisher Syndrome (MFS) and Bickerstaff Brainstem Encephalitis (BBE) form part of the same disease spectrum, sharing some clinical signs and auto-immune based mechanisms with antiganglioside antibodies. GBS, the most common cause of subacute flaccid paralysis, is a well-known and extensively described syndrome. MFS is characterized by subacute ophthalmoplegia, ataxia and areflexia. In 1957, Bickerstaff described some patients who, in addition to ataxia and ophthalmoplegia, had abnormal mental status, corresponding to brainstem involvment. Neurological manifestations associated with anti-GQ1b antibodies can occur in isolation or in association. We report the case of a woman with an unusual psychiatric presentation (peduncular hallucinosis) of anti-GQ1b antibody syndrome, with features of these three diseases, and a dramatic improvement with immunoglobulin therapy. Peduncular hallucinosis are a rare form of visual hallucination. They are often described as colourful visions of people and animals, and are usually associated with vascular lesions in the midbrain and thalamus. This provides further evidence of the broad spectrum of neurological diseases associated with antiganglioside antibodies. To the best of our knowledge this is the first description of PH complicating BBE. Clinicians should be aware of the existence of overlapping syndrome with combined central and peripherical neurological system involvement.
Keywords
Antiganglioside Antibodies Overlapping Syndromes, Guillain Barre, Miller Fisher, Bickerstaff's Brainstem Encephalitis, Peduncular Hallucinosis
To cite this article
Alexis Demas, Guillaume Costentin, Vincent Langlois, Yvan Vaschalde, Jean Philippe Cochin, Peduncular Hallucinosis and Overlapping Antiganglioside Antibody Syndrome, American Journal of Psychiatry and Neuroscience. Vol. 7, No. 1, 2019, pp. 8-11. doi: 10.11648/j.ajpn.20190701.12
Copyright
Copyright © 2019 Authors retain the copyright of this article.
This article is an open access article distributed under the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
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