Volume 4, Issue 6, November 2016, Page: 87-90
A Single-Center, Randomized, Double-Blind, Placebo-Controlled Study on the Efficacy of Clonidine in Detoxification of Opioid Dependency
Mani B. Monajemi, Department of Psychology, University of Tehran, Tehran, Iran
Seyyed Mohammad Moosavi, Department of Psychiatry, Psychiatry and Behavioral Science Research Center, Mazandaran University of Medical Sciences, Sari, Iran
Received: Sep. 19, 2016;       Accepted: Feb. 9, 2017;       Published: Mar. 9, 2017
DOI: 10.11648/j.ajpn.20160406.11      View  1989      Downloads  98
Abstract
Background: Clonidine is α² adrenergic receptor agonist with detrimental effect on locus coeruleus. It is considered as one of the detoxification drugs in order to reduce opiate withdrawal syndrome. We conducted this study in order to assess clonidine effect on withdrawal symptoms and signs. Materials and methods This double blind, clinical trial, single centered study was conducted among 104 male inpatient heroin dependent patients in Psychiatric Center. They were selected via convenient sampling method. Subsequently, they were divided randomly into two matched groups: trial–control (clonidine –placebo) groups. Withdrawal symptoms and signs based on DSM–5 were compared in groups. Results: In 14 day detoxification period (in 7th and 14th day examination), the effect of clonidine on craving and agitation (p < 0.01) was significant. With respect to other symptoms and signs, clonidine was not effective prominently. Discussion: Due to different results compared to previous studies in this area. Clonidine use with respect to opioid withdrawal syndrome needs further evaluation or may need to revise.
Keywords
Clonidine, Drug Dependency, Withdrawal Syndrome
To cite this article
Mani B. Monajemi, Seyyed Mohammad Moosavi, A Single-Center, Randomized, Double-Blind, Placebo-Controlled Study on the Efficacy of Clonidine in Detoxification of Opioid Dependency, American Journal of Psychiatry and Neuroscience. Vol. 4, No. 6, 2016, pp. 87-90. doi: 10.11648/j.ajpn.20160406.11
Copyright
Copyright © 2016 Authors retain the copyright of this article.
This article is an open access article distributed under the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
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