Volume 2, Issue 6, November 2014, Page: 83-89
Exposure to an Alarm Pheromone Combined with Footshock Stress Enhances Responsivity of the Medial Amygdala-Hippocampus Circuit
Carlos M. Contreras, Unidad Periférica del Instituto de Investigaciones Biomédicas, Universidad Nacional Autónoma de México, Xalapa, Veracruz, 91190, México; Laboratorio de Neurofarmacología, Instituto de Neuroetología, Universidad Veracruzana, Xalapa, Veracruz, 91190, México
Tania Molina-Jiménez, Laboratorio de Neurofarmacología, Instituto de Neuroetología, Universidad Veracruzana, Xalapa, Veracruz, 91190, México
Ana G. Gutiérrez-García, Laboratorio de Neurofarmacología, Instituto de Neuroetología, Universidad Veracruzana, Xalapa, Veracruz, 91190, México; Facultad de Psicología, Universidad Veracruzana, Xalapa, Veracruz, 91097, México
Received: Nov. 11, 2014;       Accepted: Nov. 19, 2014;       Published: Nov. 23, 2014
DOI: 10.11648/j.ajpn.20140206.11      View  2876      Downloads  143
Abstract
Alarm substances are released under stressful situations and may constitute signals that prevent other members of the group from encountering dangerous situations by producing fear. 2-Heptanone is an alarm pheromone that increases the neuronal firing rate in temporal lobe structures that are related to fear in the rat, such as the basal amygdala. A single stress session of unavoidable electric footshock or 2-heptanone sniffing increases the responsivity of the medial amygdala-hippocampus circuit, but unknown is the timing of action of simultaneous exposure to both stressors on the firing rate and responsivity of CA1-CA3 neurons identified by their connections with the medial amygdala nucleus. Twenty-four or 48 h after a single stress session, we obtained single-unit extracellular recordings. The firing rate was higher in the 48 h group. The peristimulus histogram showed an increase in the responsivity of amygdala-hippocampus neurons, which was more pronounced 48 h after a single stress session. The present results suggest an increase in the sensitivity of this circuit after a single stress session, seemingly representing a first step in the formation of emotional memories related to a conditioned response to fear.
Keywords
2-heptanone, Fear, Footshock, Amygdala, Hippocampus
To cite this article
Carlos M. Contreras, Tania Molina-Jiménez, Ana G. Gutiérrez-García, Exposure to an Alarm Pheromone Combined with Footshock Stress Enhances Responsivity of the Medial Amygdala-Hippocampus Circuit, American Journal of Psychiatry and Neuroscience. Vol. 2, No. 6, 2014, pp. 83-89. doi: 10.11648/j.ajpn.20140206.11
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