Volume 2, Issue 4, July 2014, Page: 50-55
Possible Effects of Lamotrigine on Liver of Wister Rats Exposed to Chemoconvulsion and Chronic Restraint Model
Sahar Mohamed Kamal Shams El Dine, Department of Pharmacology, Faculty of Medicine, University of Ain-Shams, Cairo, Egypt
Received: Aug. 9, 2014;       Accepted: Aug. 23, 2014;       Published: Sep. 10, 2014
DOI: 10.11648/j.ajpn.20140204.11      View  2737      Downloads  112
Abstract
The present study is designed to investigate the possible hepatotoxic effects of the anti-epileptic drug “lamotrigine, LTG” in adult male wister rats after picrotoxin –induced convulsions and exposure for 21 days to chronic restraint model. This was done by a trial to find out alterations in the activities of liver enzymes and some antioxidants in this model of co-morbidity. They were treated by gastric gavage with LTG [20mg/kg body wt.] for 21days. Then rats were anesthetized and dissected to remove liver and to collect blood. Selected liver enzymes [AST, ALT] and some anti-oxidant enzymes were assayed. The results indicated that the drug significantly increased the activities of glutathione peroxidase and catalase enzymes in hepatic homogenates, while it significantly decreased the level of the lipid peroxidation expressed as thiobarbituric acid-reactive substance (TBARS) in these homogenates. However, there was an elevation of tested liver enzymes ALT & AST at the end of 21 days. This revealed the occurrence of possible hepatocellular damage. The present study recommends a regular liver function and drug monitoring during the therapeutic use of this drug in epilepsy-stress co-morbidity.
Keywords
Lamotrigine, Picrotoxin, Chronic Restraint Model, Liver, Rats
To cite this article
Sahar Mohamed Kamal Shams El Dine, Possible Effects of Lamotrigine on Liver of Wister Rats Exposed to Chemoconvulsion and Chronic Restraint Model, American Journal of Psychiatry and Neuroscience. Vol. 2, No. 4, 2014, pp. 50-55. doi: 10.11648/j.ajpn.20140204.11
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