Volume 1, Issue 3, November 2013, Page: 38-46
The Role of Thiamine in Schizophrenia
Khanh vinh quốc Lương, Vietnamese American Medical Research Foundation, Westminster, California, U.S.A
Lan Thi Hoàng Nguyễn, Vietnamese American Medical Research Foundation, Westminster, California, U.S.A
Received: Sep. 3, 2013;       Published: Nov. 30, 2013
DOI: 10.11648/j.ajpn.20130103.11      View  4120      Downloads  343
Objective: Review the relationship between thiamine and schizophrenia. Methods: Information was obtained from MEDLINE. Results: Nutritional status has been related to the development of schizophrenia. Genetic studies have identified numerous factors that link thiamine to schizophrenia, including the renin angiotensin system, heme oxygenase-1, advanced glycation end products, alpha-antitrypsin, coenzyme Q10, glycogen synthetase kinase-3, and the transcription factor p53. Thiamine has also been implicated in schizophrenia via its effects on matrix metalloproteinases, the Wnt/β-catenin signaling pathway, the mitogen-activated protein kinase pathways, the reduced form of nicotinamide adenine dinucleotide phosphate, prostaglandins, cyclooxygenase-2, reactive oxidative stress, and nitric oxide synthase. Conclusions: These data suggest a role of thiamine in patients with schizophrenia. Therefore, additional investigation of thiamine in schizophrenic patients is required.
Thiamine, Schizophrenia, Transketolase, Vitamin B1
To cite this article
Khanh vinh quốc Lương, Lan Thi Hoàng Nguyễn, The Role of Thiamine in Schizophrenia, American Journal of Psychiatry and Neuroscience. Vol. 1, No. 3, 2013, pp. 38-46. doi: 10.11648/j.ajpn.20130103.11
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