Volume 1, Issue 2, September 2013, Page: 22-37
The Role of Thiamine in Autism
Khanh vinh quốc Lương, Vietnamese American Medical Research Foundation, Westminster, California, U.S.A
Lan Thi Hoàng Nguyễn, Vietnamese American Medical Research Foundation, Westminster, California, U.S.A
Received: Aug. 12, 2013;       Published: Sep. 10, 2013
DOI: 10.11648/j.ajpn.20130102.11      View  5254      Downloads  537
Abstract
Autism spectrum disorders are a group of neuro-developmental conditions characterized by varying degrees of language impairment, including verbal and non-verbal communication, impaired social skill, and repetitive behaviors. In this paper, we review the evidence for an association between autism and thiamine. A relationship between thiamine status and the development of autism has been established, with thiamine supplementation exhibiting a beneficial clinical effect on children with autism. Thiamine may involve in autism via apoptotic factors (transcription factor p53, Bcl-2, and caspase-3), neurotransmitter systems (serotonin, acetylcholine, and glutamate), and oxidative stress (prostaglandins, cyclooxygenase-2, reactive oxygen species, nitric oxide synthase, the reduced form of nicotinamide adenine dinucleotide phosphate, and mitochondrial dysfunction). In addition, thiamine has also been implicated in autism via its effects on basic myelin protein, glycogen synthetase kinase-3β, alpha-1 antitrypsin, and glyoxalase 1. Thiamine may play a role in children with autism. Additional investigation of thiamine in children with autism is needed.
Keywords
Thiamine, Autism, Vitamin B1, Transketolase
To cite this article
Khanh vinh quốc Lương, Lan Thi Hoàng Nguyễn, The Role of Thiamine in Autism, American Journal of Psychiatry and Neuroscience. Vol. 1, No. 2, 2013, pp. 22-37. doi: 10.11648/j.ajpn.20130102.11
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