@article{10.11648/j.jdmp.20160204.11,
  author = {Tsague Marthe Valentine and Fokunang N. Charles and Tembe Achick Estella and Mvondo Anne Mauricette and Afane Ela Anatole and Oben E. Julius and Ngadjui Tchaleu Bonaventure and Ntchapda Fidèle and Sokeng Dongmo Sélestin and Nyangono Biyegue Christine Fernande and Dimo Théophile and Ze Minkande Jacqueline},
  title = {Hydroethanolic Extract of Eribroma oblongum (Malvaceae) Stem Bark Prevents Hypertension, Oxidative Stress and Dyslipidemia in L-NAME Induced Hypertension in Wistar Rats},
  journal = {Journal of Diseases and Medicinal Plants},
  volume = {2},
  number = {4},
  pages = {43-50},
  doi = {10.11648/j.jdmp.20160204.11},
  url = {https://doi.org/10.11648/j.jdmp.20160204.11},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.jdmp.20160204.11},
  abstract = {Introduction: Eribroma oblongum (Malvaceae) stem bark is used in Cameroonian ethnomedicine to treat various metabolic illnesses including cardiovascular diseases. The present study was designed to investigate the mechanisms of hypotensive effects of hydroethanolic extract of Eribroma oblongum and its cardioprotective effects after a subchronic treatment. Study Design: This was a prospective cross-sectional analytical study Methodology: Preventive effects were studied after oral administration of hydroethanolic extract of Eribroma oblongum (HEEO) (100 mg/kg body weight/day) or captopril (25 mg/kg body weight/day) simultaneously with L-NAME (40 mg/kg body weight/ day) in rats for 28 days. Body weight and food intake were measured after 5 days. At the end of treatment, blood pressure and heart rate were recorded. Aorta, heart, liver and kidneys were weighted. Reduced nitrite, superoxide dismutase, catalase, gluthatione, Malondialdehyde and lipid profile were measured. Results: The extract prevented L-NAME hypertension and improved food intake and body weight of rats. HEEO improved lipid profile and antioxidant status. L-NAME caused a significant (P<0.001) increase in the levels of serum transaminase relative to the normal. L-NAME treated rats had markedly decreased catalase (CAT), superoxide dismutase (SOD), nitrite (NO2-) and reduced glutathione (GSH) levels in the tissue. Also, L-NAME caused a significant (P<0.001) induction of lipid peroxidation (MDA) in the animals tissue relative to the normal range. Administration of HEEO with L- NAME caused significant (P<0.001) inhibition of MDA relative to LNHR and augmented tissue antioxidant indices. Conclusion: The hydroethanolic stem bark extract of Eribroma oblongum showed a promising potential cardioprotective effect in L-NAME induced hypertension. This effect could be due at least in part by improving endothelial function, lipid profile and oxidative status. These findings justify the traditional use of HEEO as treatment in cardiovascular disorders and serve as a promising traditional pharmacopoeia for the development of new chemical entity in the phytomedicine development platform.},
 year = {2016}
}

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TY  - JOUR
T1  - Hydroethanolic Extract of Eribroma oblongum (Malvaceae) Stem Bark Prevents Hypertension, Oxidative Stress and Dyslipidemia in L-NAME Induced Hypertension in Wistar Rats
AU  - Tsague Marthe Valentine
AU  - Fokunang N. Charles
AU  - Tembe Achick Estella
AU  - Mvondo Anne Mauricette
AU  - Afane Ela Anatole
AU  - Oben E. Julius
AU  - Ngadjui Tchaleu Bonaventure
AU  - Ntchapda Fidèle
AU  - Sokeng Dongmo Sélestin
AU  - Nyangono Biyegue Christine Fernande
AU  - Dimo Théophile
AU  - Ze Minkande Jacqueline
Y1  - 2016/06/16
PY  - 2016
N1  - https://doi.org/10.11648/j.jdmp.20160204.11
DO  - 10.11648/j.jdmp.20160204.11
T2  - Journal of Diseases and Medicinal Plants
JF  - Journal of Diseases and Medicinal Plants
JO  - Journal of Diseases and Medicinal Plants
SP  - 43
EP  - 50
PB  - Science Publishing Group
SN  - 2469-8210
UR  - https://doi.org/10.11648/j.jdmp.20160204.11
AB  - Introduction: Eribroma oblongum (Malvaceae) stem bark is used in Cameroonian ethnomedicine to treat various metabolic illnesses including cardiovascular diseases. The present study was designed to investigate the mechanisms of hypotensive effects of hydroethanolic extract of Eribroma oblongum and its cardioprotective effects after a subchronic treatment. Study Design: This was a prospective cross-sectional analytical study Methodology: Preventive effects were studied after oral administration of hydroethanolic extract of Eribroma oblongum (HEEO) (100 mg/kg body weight/day) or captopril (25 mg/kg body weight/day) simultaneously with L-NAME (40 mg/kg body weight/ day) in rats for 28 days. Body weight and food intake were measured after 5 days. At the end of treatment, blood pressure and heart rate were recorded. Aorta, heart, liver and kidneys were weighted. Reduced nitrite, superoxide dismutase, catalase, gluthatione, Malondialdehyde and lipid profile were measured. Results: The extract prevented L-NAME hypertension and improved food intake and body weight of rats. HEEO improved lipid profile and antioxidant status. L-NAME caused a significant (P<0.001) increase in the levels of serum transaminase relative to the normal. L-NAME treated rats had markedly decreased catalase (CAT), superoxide dismutase (SOD), nitrite (NO2-) and reduced glutathione (GSH) levels in the tissue. Also, L-NAME caused a significant (P<0.001) induction of lipid peroxidation (MDA) in the animals tissue relative to the normal range. Administration of HEEO with L- NAME caused significant (P<0.001) inhibition of MDA relative to LNHR and augmented tissue antioxidant indices. Conclusion: The hydroethanolic stem bark extract of Eribroma oblongum showed a promising potential cardioprotective effect in L-NAME induced hypertension. This effect could be due at least in part by improving endothelial function, lipid profile and oxidative status. These findings justify the traditional use of HEEO as treatment in cardiovascular disorders and serve as a promising traditional pharmacopoeia for the development of new chemical entity in the phytomedicine development platform.
VL  - 2
IS  - 4
ER  - 

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