Analysis by Computer Simulation of Factors Affecting the Extracellular Slow Wave Features of the Human Colon

Nicola Mirizzi; Giuseppe Riezzo

doi:doi:10.11648/j.ijbse.20150302.12

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Analysis by Computer Simulation of Factors Affecting the Extracellular Slow Wave Features of the Human Colon

Nicola Mirizzi, Giuseppe Riezzo

Published in International Journal of Biomedical Science and Engineering (Volume 3, Issue 2)

Received: 9 March 2015 Accepted: 25 March 2015 Published: 31 March 2015

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Abstract

The study reported in this paper analyses, by computer simulation, factors affecting the features (amplitude, frequency and phase lag) of the slow waves of the extracellular myoelectrical activity of the human ascending colon. It takes into account both the anatomic and functional aspects of the colon haustra, the myoelectrical dynamics of the cells and the geometric modification of haustra’ configuration. The variable sacculated geometry of the colon wall, segmented into typical haustra, has been represented by a sequence of truncated round ellipsoids. According to the propagation of the front of depolarization-repolarization of the cells, slow waves are simulated by the cyclic movement of an annular band polarized by electrical dipoles oriented perpendicularly with respect to the surface of the ellipsoids and activated by a pacemaker. The simulation highlighted that the amplitude of the slow waves physiologically depends on the dipole moment of cells, and the frequency depends on the velocity of the polarized annular band. In addition, the amplitude, the frequency and the phase lag also depend on the dynamic modification of the geometrical factors (colon length and haustrum radius). Furthermore, the simulation results showed that the shape of the slow wave and the amplitude of its peaks depend on the inter-electrode distance and on the electrode positioning with respect to the lower edge of ellipsoids.

Published in	International Journal of Biomedical Science and Engineering (Volume 3, Issue 2)
DOI	10.11648/j.ijbse.20150302.12
Page(s)	18-24
Creative Commons	This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.
Copyright	Copyright © The Author(s), 2015. Published by Science Publishing Group

Keywords

Computer Simulation, Extracellular Myoelectrical Activity, Human Colon

References

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Nicola Mirizzi, Giuseppe Riezzo. (2015). Analysis by Computer Simulation of Factors Affecting the Extracellular Slow Wave Features of the Human Colon. International Journal of Biomedical Science and Engineering, 3(2), 18-24. https://doi.org/10.11648/j.ijbse.20150302.12

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ACS Style

Nicola Mirizzi; Giuseppe Riezzo. Analysis by Computer Simulation of Factors Affecting the Extracellular Slow Wave Features of the Human Colon. Int. J. Biomed. Sci. Eng. 2015, 3(2), 18-24. doi: 10.11648/j.ijbse.20150302.12

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AMA Style

Nicola Mirizzi, Giuseppe Riezzo. Analysis by Computer Simulation of Factors Affecting the Extracellular Slow Wave Features of the Human Colon. Int J Biomed Sci Eng. 2015;3(2):18-24. doi: 10.11648/j.ijbse.20150302.12

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@article{10.11648/j.ijbse.20150302.12,
  author = {Nicola Mirizzi and Giuseppe Riezzo},
  title = {Analysis by Computer Simulation of Factors Affecting the Extracellular Slow Wave Features of the Human Colon},
  journal = {International Journal of Biomedical Science and Engineering},
  volume = {3},
  number = {2},
  pages = {18-24},
  doi = {10.11648/j.ijbse.20150302.12},
  url = {https://doi.org/10.11648/j.ijbse.20150302.12},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ijbse.20150302.12},
  abstract = {The study reported in this paper analyses, by computer simulation, factors affecting the features (amplitude, frequency and phase lag) of the slow waves of the extracellular myoelectrical activity of the human ascending colon. It takes into account both the anatomic and functional aspects of the colon haustra, the myoelectrical dynamics of the cells and the geometric modification of haustra’ configuration. The variable sacculated geometry of the colon wall, segmented into typical haustra, has been represented by a sequence of truncated round ellipsoids. According to the propagation of the front of depolarization-repolarization of the cells, slow waves are simulated by the cyclic movement of an annular band polarized by electrical dipoles oriented perpendicularly with respect to the surface of the ellipsoids and activated by a pacemaker. The simulation highlighted that the amplitude of the slow waves physiologically depends on the dipole moment of cells, and the frequency depends on the velocity of the polarized annular band. In addition, the amplitude, the frequency and the phase lag also depend on the dynamic modification of the geometrical factors (colon length and haustrum radius). Furthermore, the simulation results showed that the shape of the slow wave and the amplitude of its peaks depend on the inter-electrode distance and on the electrode positioning with respect to the lower edge of ellipsoids.},
 year = {2015}
}

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TY  - JOUR
T1  - Analysis by Computer Simulation of Factors Affecting the Extracellular Slow Wave Features of the Human Colon
AU  - Nicola Mirizzi
AU  - Giuseppe Riezzo
Y1  - 2015/03/31
PY  - 2015
N1  - https://doi.org/10.11648/j.ijbse.20150302.12
DO  - 10.11648/j.ijbse.20150302.12
T2  - International Journal of Biomedical Science and Engineering
JF  - International Journal of Biomedical Science and Engineering
JO  - International Journal of Biomedical Science and Engineering
SP  - 18
EP  - 24
PB  - Science Publishing Group
SN  - 2376-7235
UR  - https://doi.org/10.11648/j.ijbse.20150302.12
AB  - The study reported in this paper analyses, by computer simulation, factors affecting the features (amplitude, frequency and phase lag) of the slow waves of the extracellular myoelectrical activity of the human ascending colon. It takes into account both the anatomic and functional aspects of the colon haustra, the myoelectrical dynamics of the cells and the geometric modification of haustra’ configuration. The variable sacculated geometry of the colon wall, segmented into typical haustra, has been represented by a sequence of truncated round ellipsoids. According to the propagation of the front of depolarization-repolarization of the cells, slow waves are simulated by the cyclic movement of an annular band polarized by electrical dipoles oriented perpendicularly with respect to the surface of the ellipsoids and activated by a pacemaker. The simulation highlighted that the amplitude of the slow waves physiologically depends on the dipole moment of cells, and the frequency depends on the velocity of the polarized annular band. In addition, the amplitude, the frequency and the phase lag also depend on the dynamic modification of the geometrical factors (colon length and haustrum radius). Furthermore, the simulation results showed that the shape of the slow wave and the amplitude of its peaks depend on the inter-electrode distance and on the electrode positioning with respect to the lower edge of ellipsoids.
VL  - 3
IS  - 2
ER  -

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Author Information

Nicola Mirizzi

Department of Physics, University of Bari, Bari, Italy
Giuseppe Riezzo

Laboratory of Nutritional Pathophysiology IRCCS “S. de Bellis” National Institute for Digestive Diseases Castellana Grotte (BA), Italy

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APA Style

Nicola Mirizzi, Giuseppe Riezzo. (2015). Analysis by Computer Simulation of Factors Affecting the Extracellular Slow Wave Features of the Human Colon. International Journal of Biomedical Science and Engineering, 3(2), 18-24. https://doi.org/10.11648/j.ijbse.20150302.12

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ACS Style

Nicola Mirizzi; Giuseppe Riezzo. Analysis by Computer Simulation of Factors Affecting the Extracellular Slow Wave Features of the Human Colon. Int. J. Biomed. Sci. Eng. 2015, 3(2), 18-24. doi: 10.11648/j.ijbse.20150302.12

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AMA Style

Nicola Mirizzi, Giuseppe Riezzo. Analysis by Computer Simulation of Factors Affecting the Extracellular Slow Wave Features of the Human Colon. Int J Biomed Sci Eng. 2015;3(2):18-24. doi: 10.11648/j.ijbse.20150302.12

Copy | Download

@article{10.11648/j.ijbse.20150302.12,
  author = {Nicola Mirizzi and Giuseppe Riezzo},
  title = {Analysis by Computer Simulation of Factors Affecting the Extracellular Slow Wave Features of the Human Colon},
  journal = {International Journal of Biomedical Science and Engineering},
  volume = {3},
  number = {2},
  pages = {18-24},
  doi = {10.11648/j.ijbse.20150302.12},
  url = {https://doi.org/10.11648/j.ijbse.20150302.12},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ijbse.20150302.12},
  abstract = {The study reported in this paper analyses, by computer simulation, factors affecting the features (amplitude, frequency and phase lag) of the slow waves of the extracellular myoelectrical activity of the human ascending colon. It takes into account both the anatomic and functional aspects of the colon haustra, the myoelectrical dynamics of the cells and the geometric modification of haustra’ configuration. The variable sacculated geometry of the colon wall, segmented into typical haustra, has been represented by a sequence of truncated round ellipsoids. According to the propagation of the front of depolarization-repolarization of the cells, slow waves are simulated by the cyclic movement of an annular band polarized by electrical dipoles oriented perpendicularly with respect to the surface of the ellipsoids and activated by a pacemaker. The simulation highlighted that the amplitude of the slow waves physiologically depends on the dipole moment of cells, and the frequency depends on the velocity of the polarized annular band. In addition, the amplitude, the frequency and the phase lag also depend on the dynamic modification of the geometrical factors (colon length and haustrum radius). Furthermore, the simulation results showed that the shape of the slow wave and the amplitude of its peaks depend on the inter-electrode distance and on the electrode positioning with respect to the lower edge of ellipsoids.},
 year = {2015}
}

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TY  - JOUR
T1  - Analysis by Computer Simulation of Factors Affecting the Extracellular Slow Wave Features of the Human Colon
AU  - Nicola Mirizzi
AU  - Giuseppe Riezzo
Y1  - 2015/03/31
PY  - 2015
N1  - https://doi.org/10.11648/j.ijbse.20150302.12
DO  - 10.11648/j.ijbse.20150302.12
T2  - International Journal of Biomedical Science and Engineering
JF  - International Journal of Biomedical Science and Engineering
JO  - International Journal of Biomedical Science and Engineering
SP  - 18
EP  - 24
PB  - Science Publishing Group
SN  - 2376-7235
UR  - https://doi.org/10.11648/j.ijbse.20150302.12
AB  - The study reported in this paper analyses, by computer simulation, factors affecting the features (amplitude, frequency and phase lag) of the slow waves of the extracellular myoelectrical activity of the human ascending colon. It takes into account both the anatomic and functional aspects of the colon haustra, the myoelectrical dynamics of the cells and the geometric modification of haustra’ configuration. The variable sacculated geometry of the colon wall, segmented into typical haustra, has been represented by a sequence of truncated round ellipsoids. According to the propagation of the front of depolarization-repolarization of the cells, slow waves are simulated by the cyclic movement of an annular band polarized by electrical dipoles oriented perpendicularly with respect to the surface of the ellipsoids and activated by a pacemaker. The simulation highlighted that the amplitude of the slow waves physiologically depends on the dipole moment of cells, and the frequency depends on the velocity of the polarized annular band. In addition, the amplitude, the frequency and the phase lag also depend on the dynamic modification of the geometrical factors (colon length and haustrum radius). Furthermore, the simulation results showed that the shape of the slow wave and the amplitude of its peaks depend on the inter-electrode distance and on the electrode positioning with respect to the lower edge of ellipsoids.
VL  - 3
IS  - 2
ER  -

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