Absolute Neutrophil Count as Predictor of Early Onset Sepsis

Hijrah Harmansyah; Ema Alasiry; Dasril Daud

doi:doi:10.11648/j.cmr.20150403.15

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Absolute Neutrophil Count as Predictor of Early Onset Sepsis

Hijrah Harmansyah, Ema Alasiry, Dasril Daud

Published in Clinical Medicine Research (Volume 4, Issue 3)

Received: 22 April 2015 Accepted: 6 May 2015 Published: 19 May 2015

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Abstract

Background: Infant mortality rate (IMR) was found to increase in the newborn. The most frequent causes of death are infection, prematurity, low birth weight (LBW), neonatal asphyxia and birth trauma, respectively. Absolute neutrophil count (ANC) can be used as a marker of infection because of its faster, easier, simpler and cheaper nature. Objective: The study aims to identify the influence of an increase and decline in ANC on newborns from mothers with risk factors for early onset sepsis. Methods: This study was conducted as a a prospective cohort study from December 2013 to July 2014. The population included 120 newborns whose mother has risk factors of early onset sepsis and admitted to Dr. Wahidin Sudirohusodo Hospital, and joined hospital. The subjects were divided into three groups, ANC <1800/mm3, ANC 1800-5399/mm3 and ANC >5400/mm3. Results: Newborn from mother with risk factor of infection with ANC >5400/mm3 and ANC 1800-5399/mm3 shows a significant difference with p = 0.000 (p<0.001); OR 8.143; IK 95% 2.440-27.173. Cut off point of 10.710-10890/mm3 was found from ROC analyses in ANC >5400/mm3 group with sensitivity and specificity 89.47% and 80.95% respectively; PPV (Positive predictive value) 80.95%; NPV (Negative predictive value) 89.47%; p=0.000; OR 36.125; IC 95% 5.820 – 224.224. Conclusions: Absolute neutrophil count >10.710/mm3 in a term newborn from mother with infection risk factors can be used as predictor for early onset sepsis 36 fold higher than the ANC <10.710/mm3.

Published in	Clinical Medicine Research (Volume 4, Issue 3)
DOI	10.11648/j.cmr.20150403.15
Page(s)	87-91
Creative Commons	This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.
Copyright	Copyright © The Author(s), 2015. Published by Science Publishing Group

Keywords

Early Onset Sepsis, Absolute Neutrophil Count, Predictor Factor

References

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[3]	Burgner, D., Strunk, T. Genetic Susceptibility to Neonatal Infection. Department of Neonatal Paediatrics. Australia. 2006; 19 (3): 259-63.
[4]	Schmutz, N., Henry, E., Jopling, J., Christensen, D. Expected ranges for blood neutrophil concentrations of neonates: The Manroe and Mouzinho charts revisited. J Perinatol. 2008; 28 (4): 275-81.
[5]	Bhandari, V., Wang, C., Rinder, C., Rinder, H. Hematologic profile of sepsis in neonates: neutrophil cd64 as a diagnostic marker. Pediatrics. 2008; 121: 129.
[6]	Bellig, L., Ohning, B. Neonatal sepsis. http://emedicine.medscape.com/article/978352-overview. 2014
[7]	Anwer, K., Mustafa, S. Rapid identification of neonatal sepsis. Journal of Pakistan Medical Association. 2000.
[8]	Health Ministry of Indonesia. Management of Sepsis Neonatorum. 2007.
[9]	Dzwonek AB., Neth OW., Thiebaut R., Gulczynska E., Chilton M., Hellwig T. The role of mannose-binding lectin in susceptibility to infection in preterm neonates. Pediatric Research. 2008; 63: 680-85.
[10]	Frakking, F.N.J., Brouwer, N., Eijkelenburg, N.K.A. Van, Merkus, M.P., Kuijpers, T.W., et al. Low mannose-binding lectin (MBL) levels in neonates with pneumonia and sepsis. British society for immunology, Clinical and Experimental Immunology. 2007; 150: 255-62.
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APA Style

Hijrah Harmansyah, Ema Alasiry, Dasril Daud. (2015). Absolute Neutrophil Count as Predictor of Early Onset Sepsis. Clinical Medicine Research, 4(3), 87-91. https://doi.org/10.11648/j.cmr.20150403.15

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ACS Style

Hijrah Harmansyah; Ema Alasiry; Dasril Daud. Absolute Neutrophil Count as Predictor of Early Onset Sepsis. Clin. Med. Res. 2015, 4(3), 87-91. doi: 10.11648/j.cmr.20150403.15

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AMA Style

Hijrah Harmansyah, Ema Alasiry, Dasril Daud. Absolute Neutrophil Count as Predictor of Early Onset Sepsis. Clin Med Res. 2015;4(3):87-91. doi: 10.11648/j.cmr.20150403.15

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@article{10.11648/j.cmr.20150403.15,
  author = {Hijrah Harmansyah and Ema Alasiry and Dasril Daud},
  title = {Absolute Neutrophil Count as Predictor of Early Onset Sepsis},
  journal = {Clinical Medicine Research},
  volume = {4},
  number = {3},
  pages = {87-91},
  doi = {10.11648/j.cmr.20150403.15},
  url = {https://doi.org/10.11648/j.cmr.20150403.15},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.cmr.20150403.15},
  abstract = {Background: Infant mortality rate (IMR) was found to increase in the newborn. The most frequent causes of death are infection, prematurity, low birth weight (LBW), neonatal asphyxia and birth trauma, respectively. Absolute neutrophil count (ANC) can be used as a marker of infection because of its faster, easier, simpler and cheaper nature. Objective: The study aims to identify the influence of an increase and decline in ANC on newborns from mothers with risk factors for early onset sepsis. Methods: This study was conducted as a a prospective cohort study from December 2013 to July 2014. The population included 120 newborns whose mother has risk factors of early onset sepsis and admitted to Dr. Wahidin Sudirohusodo Hospital, and joined hospital. The subjects were divided into three groups, ANC 5400/mm3. Results: Newborn from mother with risk factor of infection with ANC >5400/mm3 and ANC 1800-5399/mm3 shows a significant difference with p = 0.000 (p5400/mm3 group with sensitivity and specificity 89.47% and 80.95% respectively; PPV (Positive predictive value) 80.95%; NPV (Negative predictive value) 89.47%; p=0.000; OR 36.125; IC 95% 5.820 – 224.224. Conclusions: Absolute neutrophil count >10.710/mm3 in a term newborn from mother with infection risk factors can be used as predictor for early onset sepsis 36 fold higher than the ANC <10.710/mm3.},
 year = {2015}
}

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TY - JOUR
T1 - Absolute Neutrophil Count as Predictor of Early Onset Sepsis
AU - Hijrah Harmansyah
AU - Ema Alasiry
AU - Dasril Daud
Y1 - 2015/05/19
PY - 2015
N1 - https://doi.org/10.11648/j.cmr.20150403.15
DO - 10.11648/j.cmr.20150403.15
T2 - Clinical Medicine Research
JF - Clinical Medicine Research
JO - Clinical Medicine Research
SP - 87
EP - 91
PB - Science Publishing Group
SN - 2326-9057
UR - https://doi.org/10.11648/j.cmr.20150403.15
AB - Background: Infant mortality rate (IMR) was found to increase in the newborn. The most frequent causes of death are infection, prematurity, low birth weight (LBW), neonatal asphyxia and birth trauma, respectively. Absolute neutrophil count (ANC) can be used as a marker of infection because of its faster, easier, simpler and cheaper nature. Objective: The study aims to identify the influence of an increase and decline in ANC on newborns from mothers with risk factors for early onset sepsis. Methods: This study was conducted as a a prospective cohort study from December 2013 to July 2014. The population included 120 newborns whose mother has risk factors of early onset sepsis and admitted to Dr. Wahidin Sudirohusodo Hospital, and joined hospital. The subjects were divided into three groups, ANC 5400/mm3. Results: Newborn from mother with risk factor of infection with ANC >5400/mm3 and ANC 1800-5399/mm3 shows a significant difference with p = 0.000 (p5400/mm3 group with sensitivity and specificity 89.47% and 80.95% respectively; PPV (Positive predictive value) 80.95%; NPV (Negative predictive value) 89.47%; p=0.000; OR 36.125; IC 95% 5.820 – 224.224. Conclusions: Absolute neutrophil count >10.710/mm3 in a term newborn from mother with infection risk factors can be used as predictor for early onset sepsis 36 fold higher than the ANC <10.710/mm3.
VL - 4
IS - 3
ER -

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Author Information

Hijrah Harmansyah

Department of Pediatrics, Medical Faculty of Hasanuddin University, Makassar, Indonesia
Ema Alasiry

Department of Pediatrics, Medical Faculty of Hasanuddin University, Makassar, Indonesia
Dasril Daud

Department of Pediatrics, Medical Faculty of Hasanuddin University, Makassar, Indonesia

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APA Style

Hijrah Harmansyah, Ema Alasiry, Dasril Daud. (2015). Absolute Neutrophil Count as Predictor of Early Onset Sepsis. Clinical Medicine Research, 4(3), 87-91. https://doi.org/10.11648/j.cmr.20150403.15

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ACS Style

Hijrah Harmansyah; Ema Alasiry; Dasril Daud. Absolute Neutrophil Count as Predictor of Early Onset Sepsis. Clin. Med. Res. 2015, 4(3), 87-91. doi: 10.11648/j.cmr.20150403.15

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AMA Style

Hijrah Harmansyah, Ema Alasiry, Dasril Daud. Absolute Neutrophil Count as Predictor of Early Onset Sepsis. Clin Med Res. 2015;4(3):87-91. doi: 10.11648/j.cmr.20150403.15

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@article{10.11648/j.cmr.20150403.15,
  author = {Hijrah Harmansyah and Ema Alasiry and Dasril Daud},
  title = {Absolute Neutrophil Count as Predictor of Early Onset Sepsis},
  journal = {Clinical Medicine Research},
  volume = {4},
  number = {3},
  pages = {87-91},
  doi = {10.11648/j.cmr.20150403.15},
  url = {https://doi.org/10.11648/j.cmr.20150403.15},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.cmr.20150403.15},
  abstract = {Background: Infant mortality rate (IMR) was found to increase in the newborn. The most frequent causes of death are infection, prematurity, low birth weight (LBW), neonatal asphyxia and birth trauma, respectively. Absolute neutrophil count (ANC) can be used as a marker of infection because of its faster, easier, simpler and cheaper nature. Objective: The study aims to identify the influence of an increase and decline in ANC on newborns from mothers with risk factors for early onset sepsis. Methods: This study was conducted as a a prospective cohort study from December 2013 to July 2014. The population included 120 newborns whose mother has risk factors of early onset sepsis and admitted to Dr. Wahidin Sudirohusodo Hospital, and joined hospital. The subjects were divided into three groups, ANC 5400/mm3. Results: Newborn from mother with risk factor of infection with ANC >5400/mm3 and ANC 1800-5399/mm3 shows a significant difference with p = 0.000 (p5400/mm3 group with sensitivity and specificity 89.47% and 80.95% respectively; PPV (Positive predictive value) 80.95%; NPV (Negative predictive value) 89.47%; p=0.000; OR 36.125; IC 95% 5.820 – 224.224. Conclusions: Absolute neutrophil count >10.710/mm3 in a term newborn from mother with infection risk factors can be used as predictor for early onset sepsis 36 fold higher than the ANC <10.710/mm3.},
 year = {2015}
}

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