Arsenic is a significant environmental public health concern. The aim of the present study is to investigate the possible immunotoxic and genotoxic roles of arsenic and the ameliorative effects of quercetin and probiotics as natural antioxidants. This study was performed on male adult Wistar rats divided into six groups: control, NaAsO2-treated, quercetin-treated, probiotic–treated, NaAsO2 and quercetin-treated, and NaAsO2 and probiotics-treated. Blood samples collected from all animals were prepared for some oxidative, immunological and genetic aspects. Administration of arsenic decreased body and spleen weight, reduced serum antioxidant defense parameters and DNA content, increased liver, kidney, and brain weights, plasma malondialdehyde (MDA), myeloperoxidase (MPO), and serum cytokines (IL-1β, IL-6, TNF-α and IFN-γ). Adding quercetin to arsenic was effective in restoring the altered values of cytokines (IL-1β and IL-6), MPO, MDA, catalase (CAT) and reduced glutathione (GSH) induced by arsenic, whereas the presence of probiotics was effective in reducing genotoxicity and improving the changes of cytokines (TNF-α and IFN-γ) and superoxide dismutase (SOD). Quercetin and probiotics are excellent antioxidant therapies, through their ability to suppress reactive oxygen species ROS production, which may contribute to arsenic toxicity.
| Published in | American Journal of Life Sciences (Volume 5, Issue 4) |
| DOI | 10.11648/j.ajls.20170504.13 |
| Page(s) | 108-115 |
| Creative Commons |
This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited. |
| Copyright |
Copyright © The Author(s), 2017. Published by Science Publishing Group |
Arsenic, Quercetin, Probiotics, Oxidative Stress, Lipid Peroxidation, Inflammation
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APA Style
Abeer Saeed Alahmari, Khadiga Gamal Eldeen Adham, Ahmad Rashed Alhimaidi. (2017). Immunotoxic and Genotoxic Effects of Arsenic and Ameliorative Potential of Quercetin and Probiotics in Wistar Rat. American Journal of Life Sciences, 5(4), 108-115. https://doi.org/10.11648/j.ajls.20170504.13
ACS Style
Abeer Saeed Alahmari; Khadiga Gamal Eldeen Adham; Ahmad Rashed Alhimaidi. Immunotoxic and Genotoxic Effects of Arsenic and Ameliorative Potential of Quercetin and Probiotics in Wistar Rat. Am. J. Life Sci. 2017, 5(4), 108-115. doi: 10.11648/j.ajls.20170504.13
AMA Style
Abeer Saeed Alahmari, Khadiga Gamal Eldeen Adham, Ahmad Rashed Alhimaidi. Immunotoxic and Genotoxic Effects of Arsenic and Ameliorative Potential of Quercetin and Probiotics in Wistar Rat. Am J Life Sci. 2017;5(4):108-115. doi: 10.11648/j.ajls.20170504.13
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Download@article{10.11648/j.ajls.20170504.13,
author = {Abeer Saeed Alahmari and Khadiga Gamal Eldeen Adham and Ahmad Rashed Alhimaidi},
title = {Immunotoxic and Genotoxic Effects of Arsenic and Ameliorative Potential of Quercetin and Probiotics in Wistar Rat},
journal = {American Journal of Life Sciences},
volume = {5},
number = {4},
pages = {108-115},
doi = {10.11648/j.ajls.20170504.13},
url = {https://doi.org/10.11648/j.ajls.20170504.13},
eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ajls.20170504.13},
abstract = {Arsenic is a significant environmental public health concern. The aim of the present study is to investigate the possible immunotoxic and genotoxic roles of arsenic and the ameliorative effects of quercetin and probiotics as natural antioxidants. This study was performed on male adult Wistar rats divided into six groups: control, NaAsO2-treated, quercetin-treated, probiotic–treated, NaAsO2 and quercetin-treated, and NaAsO2 and probiotics-treated. Blood samples collected from all animals were prepared for some oxidative, immunological and genetic aspects. Administration of arsenic decreased body and spleen weight, reduced serum antioxidant defense parameters and DNA content, increased liver, kidney, and brain weights, plasma malondialdehyde (MDA), myeloperoxidase (MPO), and serum cytokines (IL-1β, IL-6, TNF-α and IFN-γ). Adding quercetin to arsenic was effective in restoring the altered values of cytokines (IL-1β and IL-6), MPO, MDA, catalase (CAT) and reduced glutathione (GSH) induced by arsenic, whereas the presence of probiotics was effective in reducing genotoxicity and improving the changes of cytokines (TNF-α and IFN-γ) and superoxide dismutase (SOD). Quercetin and probiotics are excellent antioxidant therapies, through their ability to suppress reactive oxygen species ROS production, which may contribute to arsenic toxicity.},
year = {2017}
}
TY - JOUR T1 - Immunotoxic and Genotoxic Effects of Arsenic and Ameliorative Potential of Quercetin and Probiotics in Wistar Rat AU - Abeer Saeed Alahmari AU - Khadiga Gamal Eldeen Adham AU - Ahmad Rashed Alhimaidi Y1 - 2017/08/11 PY - 2017 N1 - https://doi.org/10.11648/j.ajls.20170504.13 DO - 10.11648/j.ajls.20170504.13 T2 - American Journal of Life Sciences JF - American Journal of Life Sciences JO - American Journal of Life Sciences SP - 108 EP - 115 PB - Science Publishing Group SN - 2328-5737 UR - https://doi.org/10.11648/j.ajls.20170504.13 AB - Arsenic is a significant environmental public health concern. The aim of the present study is to investigate the possible immunotoxic and genotoxic roles of arsenic and the ameliorative effects of quercetin and probiotics as natural antioxidants. This study was performed on male adult Wistar rats divided into six groups: control, NaAsO2-treated, quercetin-treated, probiotic–treated, NaAsO2 and quercetin-treated, and NaAsO2 and probiotics-treated. Blood samples collected from all animals were prepared for some oxidative, immunological and genetic aspects. Administration of arsenic decreased body and spleen weight, reduced serum antioxidant defense parameters and DNA content, increased liver, kidney, and brain weights, plasma malondialdehyde (MDA), myeloperoxidase (MPO), and serum cytokines (IL-1β, IL-6, TNF-α and IFN-γ). Adding quercetin to arsenic was effective in restoring the altered values of cytokines (IL-1β and IL-6), MPO, MDA, catalase (CAT) and reduced glutathione (GSH) induced by arsenic, whereas the presence of probiotics was effective in reducing genotoxicity and improving the changes of cytokines (TNF-α and IFN-γ) and superoxide dismutase (SOD). Quercetin and probiotics are excellent antioxidant therapies, through their ability to suppress reactive oxygen species ROS production, which may contribute to arsenic toxicity. VL - 5 IS - 4 ER -
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