Fluoxetine for Motor Recovery After Acute Ischemic Stroke: A Randomized Placebo-Controlled Trial
Mahfuzur Rahman Babul,
Hassanuzzaman,
Zaman Ahammed,
Anwarul Kibria,
Golam Faruk,
Akramul Azam,
Mizanur Rahman
Issue:
Volume 5, Issue 3, May 2017
Pages:
31-36
Received:
3 April 2017
Accepted:
19 April 2017
Published:
31 May 2017
Abstract: Hemiplegia and hemiparesis are the most common deficits caused by stroke. A few small clinical trials suggest that Fluoxetine enhances motor recovery but its clinical efficacy is unknown in our setting. A randomized placebo-controlled trial was conducted at Neurology and medicine ward of Chittagong Medical College Hospital from 1/1/2013 to 31/12/2013. One hundred and twenty eight patients, aged between 40-60 years with a diagnosis of acute ischaemic stroke who fulfilled the defined inclusion and exclusion criteria were selected for the study. Eligible patients were randomly assigned, using a simple lottery method, in a 1:1 ratio to Fluoxetine (20 mg once per day, orally) or placebo group for 3 months starting within 10 days after the onset of stroke. The primary outcome was the mean change in the Rivermead Mobility Index (RMI) score between inclusion (day 0) and day 90. RMI score was significantly changed from D 0 to D 90 in Fluoxetine group in comparison to placebo group (p <.001) and mean (±SD) improvement of RMI score in 90 days were significantly greater in the Fluoxetine group, than in the placebo group [7.08 (±3.26) vs. 4.40 (±2.53)]. Patients treated with Fluoxetine were nearly 3.2 times more likely to show motor improvement than placebo group and the NNT was 2. In patients with acute ischaemic stroke and with motor deficit, the early administration of Fluoxetine with physiotherapy enhanced motor recovery after 3 months.
Abstract: Hemiplegia and hemiparesis are the most common deficits caused by stroke. A few small clinical trials suggest that Fluoxetine enhances motor recovery but its clinical efficacy is unknown in our setting. A randomized placebo-controlled trial was conducted at Neurology and medicine ward of Chittagong Medical College Hospital from 1/1/2013 to 31/12/20...
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An Alarming Situation of Suicide Patterns and Methods Involved in Pakistan
Adnan Liaqat,
Aisha Barlas,
Talal Barlas,
Muhammad Adnan,
Ishtiaq Anwar
Issue:
Volume 5, Issue 3, May 2017
Pages:
37-39
Received:
5 April 2017
Accepted:
21 April 2017
Published:
31 May 2017
Abstract: The act of deliberately killing an individual’s own life is known as suicide. Suicide is an important social issue and major cause of mortality Worldwide. The data was obtained from Pakistan Ordinance Factories (POF) Hospital WahCantt, Tehsil Headquarter hospital Taxila and Hassan Abdal, Pakistan. Retrospective study design was used to review suicidal cases during 2013-2014 in three health centers of Pakistan. “A Guide for Manner of Death Classification” was used for assessing the suicidal identification criteria by National Association of Medical Examiners. Chi-square test was applied to see the association between qualitative variables. A total of 100 cases were retrieved.The mean age was found to be 27.12±10.11 years. The peak age of suicidal attempts was seen in 20-30 years of age. The suicidal rate was found to be higher among males 29.99±12.73 than females 23.03±7.669. Study found out that suicide methods among all cases are 40% drug overdose, 20% wrist cutting, 10% hanging, 10% jumping from height, 10% chemical poising and 10% suicidal burns. The suicide rate is higher among Pakistani population but it was underestimated due to lack of reporting, cultural and religious reasons. Effective prevention requires a clear understanding of the size of the problem, its distribution in the population, and the major risk and protective factors at the levels of the individual, the family and the community.
Abstract: The act of deliberately killing an individual’s own life is known as suicide. Suicide is an important social issue and major cause of mortality Worldwide. The data was obtained from Pakistan Ordinance Factories (POF) Hospital WahCantt, Tehsil Headquarter hospital Taxila and Hassan Abdal, Pakistan. Retrospective study design was used to review suici...
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